Let’s be honest!

The total joint fluid is
renewed every two hours on average!

The joint fluid is in a constant state of flux and has an exceptionally fast metabolism. It is a viscous fluid produced by the joint membrane. It covers the synovial membrane in a thin layer, filling unevenness and the joint cavity.

The extremely rapid exchange makes the topical application of different drugs almost impossible, as the residence time is measured in hours as opposed to the required length of the therapy.

The main purpose of the use of topical hyaluronic acid preparations is to provide long-lasting pain relief and to improve mobility. Achieving this goal has led to the development of chemically modified, single-use formulations that are resistant to degradation processes and have a long-lasting effect!

Optivisc Single™

drastically stretched
resident time

Optivisc Single™

drastically
stretched
resident time

Cross-links CL-HA

The longer intra-articular residence time of Optivisc Single™ is the result of the stabilising cross-linking process. As a consequence of cross-linking, individual hyaluronic acid molecules are unable to move independently, which is likely to result in limited exposure with regard to the catabolism (degradation) of hyaluronic acid molecules. The cross-linked structure is also a major obstacle for extracellular degradation processes and enzymes, making it difficult to reach the degradation sites.

Monophase
particles

In the patented production process of Optivisc Single™, the cross-linking of the hyaluronic acid chains occurs in a single step, using a so-called monophase technique. The monophase process creates an extremely homogeneous super-structure of microspheres weighing billions of daltons. The homogeneous gel, despite the higher active ingredient content (density), remains easy to apply.

Single-shot
application!

Thanks to the cross-linked structure, the intra-articular residence time of Optivisc Single™ is significantly increased, allowing for single-shot application.

Single-shot
application!

Thanks to the cross-linked structure, the intra-articular residence time of Optivisc Single™ is significantly increased, allowing for single-shot application.

Single-shot application
has clear benefits.

Thanks to the cross-linked structure, the intra-articular residence time of Optivisc Single™
is drastically increased compared to linear low
molecular weight hyaluronic acid formulations.
Allowing for single-shot application. Learn more >